Compensatory mechanisms in Parkinson's disease: Circuits adaptations and role in disease modification.

Abstract

The motor features of Parkinson's disease (PD) are well known to manifest only when striatal dopaminergic deficit reaches 60-70%. Thus, PD has a long pre-symptomatic and pre-motor evolution during which compensatory mechanisms take place to delay the clinical onset of disabling manifestations. Classic compensatory mechanisms have been attributed to changes… (More)
DOI: 10.1016/j.expneurol.2017.10.002

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