Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase.

@article{Erb2001CompensatoryME,
  title={Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase.},
  author={Christina Erb and Jaap Troost and Sebastian Kopf and Ulrich Schmitt and Konrad L{\"o}ffelholz and Hermona Soreq and Jochen Klein},
  journal={Journal of neurochemistry},
  year={2001},
  volume={77 2},
  pages={638-46}
}
Central cholinergic neurotransmission was studied in learning-impaired transgenic mice expressing human acetylcholinesterase (hAChE-Tg). Total catalytic activity of AChE was approximately twofold higher in synaptosomes from hippocampus, striatum and cortex of hAChE-Tg mice as compared with controls (FVB/N mice). Extracellular acetylcholine (ACh) levels in the hippocampus, monitored by microdialysis in the absence or presence of 10(-8)-10(-3) M neostigmine in the perfusion fluid, were… CONTINUE READING