Compensatory enlargement of synaptic size in aging and senile dementia.


Synaptic contact zones in the dentate gyrus supragranular layer and cerebellar glomeruli of autoptic samples from adult, old and demented patients have been investigated by means of computer-assisted morphometric techniques. In physiological aging and senile dementia, the synaptic average area was significantly increased as compared with adult values in… (More)


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