Compensatory activations in patients with multiple sclerosis during preserved performance on the auditory N-back task.

@article{Forn2007CompensatoryAI,
  title={Compensatory activations in patients with multiple sclerosis during preserved performance on the auditory N-back task.},
  author={C. Forn and Alfonso Barr{\'o}s-Loscertales and Joaqu{\'i}n Escudero and Vicente Benlloch and Salvador Campos and Maria Ant{\`o}nia Parcet and C{\'e}sar {\'A}vila},
  journal={Human brain mapping},
  year={2007},
  volume={28 5},
  pages={424-30}
}
Recent fMRI studies have suggested that multiple sclerosis (MS) patients show adaptive cortical changes (i.e., compensatory mechanisms) during motor and cognitive tasks to limit the clinical impact of tissue injury. In this study, we investigated the activation pattern during the auditory n-back working memory (WM) paradigm in a group of 17 MS patients and 10 healthy controls with preserved performance in WM tasks. Compared with healthy controls, MS patients showed significantly greater… CONTINUE READING

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