Compensation of fitness costs and reversibility of antibiotic resistance mutations.

@article{Wiesch2010CompensationOF,
  title={Compensation of fitness costs and reversibility of antibiotic resistance mutations.},
  author={Pia Schulz zur Wiesch and Jan Engelst{\"a}dter and Sebastian Bonhoeffer},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 5},
  pages={2085-95}
}
Strains of bacterial pathogens that have acquired mutations conferring antibiotic resistance often have a lower growth rate and are less invasive or transmissible initially than their susceptible counterparts. However, fitness costs of resistance mutations can be ameliorated by secondary site mutations. These so-called compensatory mutations may restore fitness in the absence and/or presence of antimicrobials. We review literature data and show that the fitness gains in the absence and presence… CONTINUE READING