Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans.

@article{Scott1999CompellingTE,
  title={Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans.},
  author={Michael R. Van Scott and Robert Will and James Ironside and Hoang X. Nguyen and Patrick Tremblay and Stephen J. DeArmond and Stanley B Prusiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 26},
  pages={15137-42}
}
There is growing concern that bovine spongiform encephalopathy (BSE) may have passed from cattle to humans. We report here that transgenic (Tg) mice expressing bovine (Bo) prion protein (PrP) serially propagate BSE prions and that there is no species barrier for transmission from cattle to Tg(BoPrP) mice. These same mice were also highly susceptible to a new variant of Creutzfeldt-Jakob disease (nvCJD) and natural sheep scrapie. The incubation times (approximately 250 days), neuropathology, and… CONTINUE READING

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