• DOI:10.1016/J.JPBA.2004.01.012
Corpus ID: 43136102

Compatibility studies between isosorbide mononitrate and selected excipients used in the development of extended release formulations.

@article{Verma2004CompatibilitySB,
  title={Compatibility studies between isosorbide mononitrate and selected excipients used in the development of extended release formulations.},
  author={R. Verma and S. Garg},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2004},
  volume={35 3},
  pages={
          449-58
        }
}

R. Verma, S. Garg

Published 2004

Medicine, Chemistry

Journal of pharmaceutical and biomedical analysis

Techniques of thermal and isothermal stress testing (IST) were used to evaluate the compatibility of isosorbide mononitrate (IMN) with selected excipients used in the development of extended release formulations. In the first phase of the study, differential scanning calorimeter (DSC) was used as a tool to detect any interaction. In the next phase, excipients defined in the prototype formula were tested for their compatibility with IMN using IST. Based on the results, cellulose acetate and MCC… CONTINUE READING

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