Compartmentation of guanine nucleotide precursors for DNA synthesis.


We have studied the kinetics of guanine incorporation into DNA in mouse T-lymphoma (S-49) mutant cells [PNPase (purine-nucleoside phosphorylase)- and HGPRTase (hypoxanthine: guanine phosphoribosyltransferase)-deficient] that are incapable of converting dGuo (deoxyguanosine) to Gua (guanine) ribonucleotides. Of the two possible pathways for an exogenous… (More)


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@article{Nguyen1986CompartmentationOG, title={Compartmentation of guanine nucleotide precursors for DNA synthesis.}, author={B. T. Nguyen and Wolfgang Sadee}, journal={The Biochemical journal}, year={1986}, volume={234 2}, pages={263-9} }