Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle.

@article{Lynch1983CompartmentationOG,
  title={Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle.},
  author={Ronald M. Lynch and Richard J. Paul},
  journal={Science},
  year={1983},
  volume={222 4630},
  pages={1344-6}
}
Vascular smooth muscle is characterized by a high rate of aerobic lactate production, which may be altered independently of oxidative phosphorylation. This finding suggested a cytoplasmic compartmentation of metabolism. Exogenous glucose was found to be the sole precursor of aerobic glycolysis under unstimulated conditions. Although tissue depolarization with high K+ resulted in a substantial reduction of endogenous glycogen, exogenous glucose remained the sole precursor of aerobic lactate… CONTINUE READING

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