Compartmentation of glutathione: implications for the study of toxicity and disease.

@article{Smith1996CompartmentationOG,
  title={Compartmentation of glutathione: implications for the study of toxicity and disease.},
  author={Charles V Smith and Dean P. Jones and Thomas M. Guenthner and Lawrence H Lash and Bernhard H. Lauterburg},
  journal={Toxicology and applied pharmacology},
  year={1996},
  volume={140 1},
  pages={
          1-12
        }
}
The fact that glutathione (GSH) plays many roles in biological protective mechanisms and critical physiological functions has been recognized for decades. Conjugates, disulfides, and other glutathione-derived products also have been studied as biomarkers of the chemical natures or specific identities of key metabolites of toxic agents and such studies have been crucial in the delineation of the nature of the interactions of proximal toxicants with target biomolecules. Despite the extensive… CONTINUE READING
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