Compartmentation of free amino acids for protein synthesis in rat liver.

  title={Compartmentation of free amino acids for protein synthesis in rat liver.},
  author={J A Airhart and Alda Vidrich and E. A. Khairallah},
  journal={The Biochemical journal},
  volume={140 3},
The concept that a general intracellular pool serves as the sole precursor of amino acids for protein biosynthesis has been vigorously debated in recent years. To help resolve this controversy, we followed the distribution of intraperitoneally administered [(3)H]valine in the tRNA and the extracellular and intracellular compartments of rat liver. The specific radioactivity of the valine released from isolated tRNA was 2-3 times higher than that of intracellular valine, suggesting that the… CONTINUE READING

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