Compartmentation of brain glutamate metabolism in neurons and glia.

  title={Compartmentation of brain glutamate metabolism in neurons and glia.},
  author={Yevgeny Daikhin and Marc Yudkoff},
  journal={The Journal of nutrition},
  volume={130 4S Suppl},
Intrasynaptic [glutamate] must be kept low in order to maximize the signal-to-noise ratio after the release of transmitter glutamate. This is accomplished by rapid uptake of glutamate into astrocytes, which convert glutamate into glutamine. The latter then is released to neurons, which, via mitochondrial glutaminase, form the glutamate that is used for neurotransmission. This pattern of metabolic compartmentation is the "glutamate-glutamine cycle." This model is subject to the following two… 

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