Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila.

@article{Dechen2015CompartmentalizedZD,
  title={Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila.},
  author={Kesang Dechen and Christopher D. Richards and Jessica Charlotte Lye and Joab E. C. Hwang and Richard Burke},
  journal={The international journal of biochemistry & cell biology},
  year={2015},
  volume={60},
  pages={23-33}
}
Movement of zinc ions across cellular membranes is achieved mainly by two families of zinc transport genes encoding multi-transmembrane domain proteins. Members of the Zip family generally transport zinc into the cytosol, either from outside the cell or from the lumen of subcellular organelles such as the endoplasmic reticulum, Golgi, endosomes or storage vacuoles. ZnT proteins move zinc in the opposite direction, resulting in efflux from the cell or uptake into organelles. Zinc homeostasis at… CONTINUE READING
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