Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons.

@article{Kanamori2013CompartmentalizedCT,
  title={Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons.},
  author={Takahiro Kanamori and Makoto I. Kanai and Yusuke Dairyo and Kei-ichiro Yasunaga and Rei K. Morikawa and Kazuo Emoto},
  journal={Science},
  year={2013},
  volume={340 6139},
  pages={1475-8}
}
Dendrite pruning is critical for sculpting the final connectivity of neural circuits as it removes inappropriate projections, yet how neurons can selectively eliminate unnecessary dendritic branches remains elusive. Here, we show that calcium transients that are compartmentalized in specific dendritic branches act as temporal and spatial cues to trigger pruning in Drosophila sensory neurons. Calcium transients occurred in local dendrites at ~3 hours before branch elimination. In dendritic… CONTINUE READING