Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea.

@article{Jagger2006CompartmentalizedAS,
  title={Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea.},
  author={Daniel J Jagger and Andrew Forge},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 4},
  pages={1260-8}
}
Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric configuration. We investigated the functional and structural properties of native cochlear gap junctions in rats, from birth to the onset of hearing [postnatal day 12 (P12)]. Confocal immunofluorescence revealed increasing Cx26 and Cx30 expression… CONTINUE READING

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