Compartmentalized Ras/MAPK signaling.

  title={Compartmentalized Ras/MAPK signaling.},
  author={Adam Mor and Mark R Philips},
  journal={Annual review of immunology},
Signal transduction down the Ras/MAPK pathway, including that critical to T cell activation, proliferation, and differentiation, has been generally considered to occur at the plasma membrane. It is now clear that the plasma membrane does not represent the only platform for Ras/MAPK signaling. Moreover, the plasma membrane itself is no longer considered a uniform structure but rather a patchwork of microdomains that can compartmentalize signaling. Signaling on internal membranes was first… CONTINUE READING
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