Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin.

@article{Liu1998CompartmentalizationOP,
  title={Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin.},
  author={Yewei Liu and Larry Casey and Linda J. Pike},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={245 3},
  pages={684-90}
}
In cells that exhibit caveolae, the hormone-sensitive pool of PtdIns 4,5-P2 is localized in a low density, caveolin-enriched membrane fraction (1). Neuro 2a cells do not express caveolin. Nonetheless, the PtdIns 4,5-P2 in these cells is compartmentalized in a low density, detergent-insoluble domain that also contains other signaling-related molecules. Compartmentalization of PtdIns 4,5-P2 was observed regardless of whether Triton X-100-containing or detergent-free methods were used to prepare… CONTINUE READING