Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury.

@article{Awad2009CompartmentalizationON,
  title={Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury.},
  author={Alaa S. Awad and Michael D Rouse and Liping Huang and Amy L Vergis and J{\"o}rg Reutershan and Helen P. Cathro and Joel M Linden and Mark Douglas Okusa},
  journal={Kidney international},
  year={2009},
  volume={75 7},
  pages={689-98}
}
During renal ischemia-reperfusion, local and distant tissue injury is caused by an influx of neutrophils into the affected tissues. Here we measured the kinetics of margination and transmigration of neutrophils in vivo in the kidney and lungs following renal ischemia-reperfusion. After bilateral renal injury, kidney neutrophil content increased threefold at 24 h. The neutrophils were found primarily in the interstitium and to a lesser degree marginated to the vascular endothelium. These… CONTINUE READING