Compartmentalization of integrin α6β4 signaling in lipid rafts

  title={Compartmentalization of integrin α6β4 signaling in lipid rafts},
  author={Laurent Gagnoux-Palacios and Michael J Dans and Wouter van't Hof and Agnese Mariotti and Angela Pepe and Guerrino Meneguzzi and Marilyn D. Resh and Filippo G. Giancotti},
  journal={The Journal of Cell Biology},
  pages={1189 - 1196}
Integrin alpha6beta4 signaling proceeds through Src family kinase (SFK)-mediated phosphorylation of the cytoplasmic tail of beta4, recruitment of Shc, and activation of Ras and phosphoinositide-3 kinase. Upon cessation of signaling, alpha6beta4 mediates assembly of hemidesmosomes. Here, we report that part of alpha6beta4 is incorporated in lipid rafts. Metabolic labeling in combination with mutagenesis indicates that one or more cysteine in the membrane-proximal segment of beta4 tail is… CONTINUE READING