Compartmentalization of hepatitis C virus quasispecies in blood mononuclear cells of patients with mixed cryoglobulinemic syndrome.

@article{Zehender2005CompartmentalizationOH,
  title={Compartmentalization of hepatitis C virus quasispecies in blood mononuclear cells of patients with mixed cryoglobulinemic syndrome.},
  author={Gianguglielmo Zehender and Chiara De Maddalena and Flavia Bernini and Erika Ebranati and Giuseppe Monti and Piero Pioltelli and Massimo Galli},
  journal={Journal of virology},
  year={2005},
  volume={79 14},
  pages={9145-56}
}
The aim of this study was to investigate the quasispecies heterogeneity of hepatitis C virus (HCV) in the plasma, cryoprecipitate, and peripheral lymphocytes of chronically infected HCV patients with mixed cryoglobulinemia (MC). We studied 360 clones from 10 HCV-positive patients with MC and 8 age-, gender- and HCV genotype-matched subjects with chronic HCV infection but without MC. A partial nucleotide sequence encompassing the E1/E2 region, including hypervariable region 1 (HVR1), was… CONTINUE READING
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