Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.

  title={Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.},
  author={Eva V Wertheimer and Dar{\'i}o Krapf and Jos{\'e} Luis de la Vega-Beltr{\'a}n and Claudia S{\'a}nchez-C{\'a}rdenas and Felipe A. Navarrete and Douglas Haddad and Jessica Escoffier and Ana Mar{\'i}a Salicioni and Lonny R. Levin and Jochen Buck and Jesse Mager and Alberto Darszon and Pablo E Visconti},
  journal={The Journal of biological chemistry},
  volume={288 49},
Fertilization competence is acquired in the female tract in a process known as capacitation. Capacitation is needed for the activation of motility (e.g. hyperactivation) and to prepare the sperm for an exocytotic process known as acrosome reaction. Although the HCO3(-)-dependent soluble adenylyl cyclase Adcy10 plays a role in motility, less is known about the source of cAMP in the sperm head. Transmembrane adenylyl cyclases (tmACs) are another possible source of cAMP. These enzymes are… CONTINUE READING