Compartmentalization of androgen receptor protein–protein interactions in living cells

  title={Compartmentalization of androgen receptor protein–protein interactions in living cells},
  author={Martin E van Royen and S{\'o}nia M. Cunha and Maartje C. Brink and Karin A. Mattern and Alex L. Nigg and Hendrikus Jan Dubbink and Pernette J. Verschure and Jan Trapman and Adriaan B. Houtsmuller},
  journal={The Journal of Cell Biology},
  pages={63 - 72}
Steroid receptors regulate gene expression in a ligand-dependent manner by binding specific DNA sequences. Ligand binding also changes the conformation of the ligand binding domain (LBD), allowing interaction with coregulators via LxxLL motifs. Androgen receptors (ARs) preferentially interact with coregulators containing LxxLL-related FxxLF motifs. The AR is regulated at an extra level by interaction of an FQNLF motif in the N-terminal domain with the C-terminal LBD (N/C interaction). Although… CONTINUE READING


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