Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences

  title={Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences},
  author={Elaine W. Raines and Russell R. Ross},
  journal={The Journal of Cell Biology},
  pages={533 - 543}
The PDGFs are a family of molecules assembled as disulfide-bonded homo- and heterodimers from two distinct but highly homologous polypeptide chains (PDGF-A and PDGF-B). Two PDGF A-chain transcripts, which arise from alternative usage of the 69-bp exon 6 and exon 7, give rise to two forms of PDGF-A. In spite of the conservation of two PDGF A-chain forms over at least 350 million years, no differences in their biological activities have been identified. We have investigated the activity of the… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 70 references

Anovelmechanism regulating growth factor association with the the cell surface : identification of a PDGF retention domain

  • D. W. Maher, M. Hannink, D. J. Donoghue
  • Genes & Dev .
  • 1991

Identification of a cell retention signal in the B - chain of platelet - derived growth factor and in the long splice version of the A - chain

  • R. Ross
  • Cell Reg .
  • 1991

A polybasic domain and palmitoylation is required in addition to the CAAX motif to localize p 21 - to the plasma membrane

  • J. W. Forstrom, J. D. Kelly, +4 authors D. F. Bowen-Pope
  • Cell .
  • 1990

Analogou s alternative splicing

  • D. F. Bowen-Pope, R. Ross
  • Nature ( Land . ) .
  • 1990

Differentiatio n inhibiting activity is produced in matrix - associated and diffusible forms that are generated by alternative promoter usage

  • M. F. Roussel, R. A. Ashmun, P. Ralph, K. Price, C. J. Sherr
  • Cell .
  • 1990

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