Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences

@article{Raines1992CompartmentalizationOP,
  title={Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences},
  author={Elaine W. Raines and Russell R. Ross},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={116},
  pages={533 - 543}
}
The PDGFs are a family of molecules assembled as disulfide-bonded homo- and heterodimers from two distinct but highly homologous polypeptide chains (PDGF-A and PDGF-B). Two PDGF A-chain transcripts, which arise from alternative usage of the 69-bp exon 6 and exon 7, give rise to two forms of PDGF-A. In spite of the conservation of two PDGF A-chain forms over at least 350 million years, no differences in their biological activities have been identified. We have investigated the activity of the… CONTINUE READING

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