Compartmentalization from the outside: the extracellular matrix and functional microdomains in the brain

@article{Dityatev2010CompartmentalizationFT,
  title={Compartmentalization from the outside: the extracellular matrix and functional microdomains in the brain},
  author={Alexander Dityatev and Constanze I. Seidenbecher and Melitta Schachner},
  journal={Trends in Neurosciences},
  year={2010},
  volume={33},
  pages={503-512}
}
The extracellular matrix (ECM) of the central nervous system is well recognized as a migration and diffusion barrier that allows for the trapping and presentation of growth factors to their receptors at the cell surface. Recent data highlight the importance of ECM molecules as synaptic and perisynaptic scaffolds that direct the clustering of neurotransmitter receptors in the postsynaptic compartment and that present barriers to reduce the lateral diffusion of membrane proteins away from… CONTINUE READING

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