Compartmental pharmacokinetics and tissue distribution of multilamellar liposomal nystatin in rabbits.

  title={Compartmental pharmacokinetics and tissue distribution of multilamellar liposomal nystatin in rabbits.},
  author={Andreas H Groll and Diana Mickiene and Korin Werner and Ruta Petraitiene and Vidmantas Petraitis and M Calendario and Aida Field-Ridley and John Crisp and Stephen C. Piscitelli and Thomas J Walsh},
  journal={Antimicrobial agents and chemotherapy},
  volume={44 4},
The plasma pharmacokinetics of multilamellar liposomal nystatin were studied in normal, catheterized rabbits after single and multiple daily intravenous administration of dosages of 2, 4, and 6 mg/kg of body weight, and drug levels in tissues were assessed after multiple dosing. Concentrations of liposomal nystatin were measured as those of nystatin by a validated high-performance liquid chromatography method, and plasma concentration data were fitted into a two-compartment open model. Across… CONTINUE READING
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High - performance liquid chromatographic determination of liposomal nystatin in plasma and tissues for pharmacokinetic and tissue distribution stud

  • A. H. Groll, V. Petraitis, +5 authors T. J. Walsh
  • 1999

History of antifungal therapy

  • V. T. Andriole
  • Infect. Dis. Clin. Pract. 7(Suppl
  • 1998

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