Compartmental neurodegeneration and synaptic plasticity in the Wld(s) mutant mouse.

@article{Gillingwater2001CompartmentalNA,
  title={Compartmental neurodegeneration and synaptic plasticity in the Wld(s) mutant mouse.},
  author={Thomas H Gillingwater and Richard R Ribchester},
  journal={The Journal of physiology},
  year={2001},
  volume={534 Pt 3},
  pages={627-39}
}
This review focuses on recent developments in our understanding of neurodegeneration at the mammalian neuromuscular junction. We provide evidence to support a hypothesis of compartmental neurodegeneration, whereby synaptic degeneration occurs by a separate, distinct mechanism from cell body and axonal degeneration. Studies of the spontaneous mutant Wld(s) mouse, in which Wallerian degeneration is characteristically slow, provide key evidence in support of this hypothesis. Some features of… CONTINUE READING

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