Compartmental immunophenotyping in COVID-19 ARDS: A case series

@article{Ronit2020CompartmentalII,
  title={Compartmental immunophenotyping in COVID-19 ARDS: A case series},
  author={Andreas Ronit and Ronan M.G. Berg and Jakob T Bay and Anna Karen Haugaard and Magnus Glindvad Ahlstr{\"o}m and Kristoffer S Burgdorf and Henrik Ullum and Sara B. R{\o}rvig and Klaus Tjelle and Nicolai Bang Foss and Thomas Lars Benfield and Hanne Vibeke Marquart and Ronni R. Plovsing},
  journal={The Journal of Allergy and Clinical Immunology},
  year={2020},
  volume={147},
  pages={81 - 91}
}
  • A. Ronit, R. Berg, R. Plovsing
  • Published 23 September 2020
  • Medicine, Biology
  • The Journal of Allergy and Clinical Immunology

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References

SHOWING 1-10 OF 47 REFERENCES

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

TLDR
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe COVID-19 and the presence of clonally expanded CD8 + T cells in Patients with moderate CO VID-19.

Eosinophil responses during COVID-19 infections and coronavirus vaccination

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.

TLDR
In this small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

T helper 17 cells are involved in the local and systemic inflammatory response in community-acquired pneumonia

TLDR
Data indicate that Th 17 cells are engaged in the local and systemic immune response in human pneumonia, especially, IL-17A/IL-22 double positive Th17 cells may be involved in the immunopathogenesis of CAP.

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

TLDR
The high incidence of thromboembolic events suggests an important role of COVID-19–induced coagulopathy, as well as possible therapeutic interventions to reduce it, in patients dying with a polymerase chain reaction–confirmed diagnosis of CO VID-19.

COVID-19 with Different Severities: A Multicenter Study of Clinical Features

  • Yun FengY. Ling J. Qu
  • Medicine
    American journal of respiratory and critical care medicine
  • 2020
TLDR
Multiple organ dysfunction and impaired immune function were the typical characteristics of patients with severe or critical illness and there was a significant difference in the use of angiotensin-converting enzyme inhibitors/angiotens in II receptor blockers among patients with different severities of disease.

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

TLDR
In patients hospitalized with COVID-19, dexamethasone reduced 28-day mortality among those receiving invasive mechanical ventilation or oxygen at randomization, but not among patients not receiving respiratory support.

Bronchoalveolar lavage cell pattern from healthy human lung

TLDR
The data suggest that age corrected BAL fluid CD4+/CD8+ ratios should be used in the clinical evaluation of patients with interstitial lung diseases.

Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis

TLDR
Abnormal haematological variables were common among patients with SARS and the depletion of T lymphocyte subsets may be associated with disease activity.