Compartmental Models Simulating a Dichotomy of Action Potential Backpropagation in Ca1 Pyramidal Neuron Dendrites

@article{Kath2001CompartmentalMS,
  title={Compartmental Models Simulating a Dichotomy of Action Potential Backpropagation in Ca1 Pyramidal Neuron Dendrites},
  author={William L. Kath and Nace L. Golding and Nelson Spruston},
  journal={Computational Biology eJournal},
  year={2001}
}
In hippocampal CA1 pyramidal neurons, action potentials are typically initiated in the axon and backpropagate into the dendrites, shaping the integration of synaptic activity and influencing the induction of synaptic plasticity. Despite previous reports describing action-potential propagation in the proximal apical dendrites, the extent to which action potentials invade the distal dendrites of CA1 pyramidal neurons remains controversial. Using paired somatic and dendritic whole cell recordings… Expand
Dynamics of action potential backpropagation in basal dendrites of prefrontal cortical pyramidal neurons
TLDR
The results show that the AP‐failure concept does not apply in all basal dendrites of the rat prefrontal cortex, and the majority of synaptic contacts in the basilar dendritic tree actually received significant AP‐associated electrical and calcium transients. Expand
Quantitative assessment of the distributions of membrane conductances involved in action potential backpropagation along basal dendrites.
TLDR
The hypothesis that a fraction of basal branches may have different membrane properties compared with sister branches in the same dendritic tree is discussed, and the mechanisms underlying two sets of published data involving high-frequency trains of APs and the local generation of sodium spikelets are explored. Expand
The stochastic nature of action potential backpropagation in apical tuft dendrites.
TLDR
The stochastic nature of bAP-Ca2+ adds a new perspective on the mechanisms by which pyramidal neurons combine inputs arriving at different cortical layers by quantifying the time delay between the somatic AP burst and the peak of dendritic Ca2+ transient in the apical tuft. Expand
Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites
TLDR
Simulations suggest that synaptic potentials attenuate enormously as they propagate from the dendrite to the soma, with greater than 100‐fold attenuation for synapses on many small, distal dendrites, suggesting that distal synaptic inputs are likely only to be effective in the presence of conductance scaling, dendritic excitability, or both. Expand
Roles of IA and morphology in action potential propagation in CA1 pyramidal cell dendrites
TLDR
It is found that non-uniform activation properties of IA can lead to backpropagation failure similar to that observed experimentally in CA1 pyramidal cells, which suggests an important functional role of bAPs, which are known to be prone to failure in distal locations. Expand
Sodium Channels and Dendritic Spike Initiation at Excitatory Synapses in Globus Pallidus Neurons
TLDR
The ability of small amounts of excitation to trigger spikes in GP dendrites supports the prominent role of subthalamic input in the control of GP activity and indicates that postsynaptic sodium channel clustering is an effective mechanism to mediate a novel form of synaptic amplification and dendritic spike initiation. Expand
Active dendrites, potassium channels and synaptic plasticity.
  • D. Johnston, B. Christie, +5 authors L. Yuan
  • Chemistry, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2003
TLDR
The results support the view that the active properties of dendrites play important roles in synaptic integration and synaptic plasticity of these neurons. Expand
Action Potential Initiation and Propagation in Layer 5 Pyramidal Neurons of the Rat Prefrontal Cortex: Absence of Dopamine Modulation
TLDR
Data indicate that AP backpropagation in prefrontal layer 5 pyramidal neurons is robust but frequency dependent in the distal tuft, requires dendritic sodium rather than calcium channel activation, and, unlike other aspects of neuronal excitability, insensitive to modulation by dopamine. Expand
Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons
TLDR
The perforant-path projection to the hippocampus forms synapses in the apical tuft of CA1 pyramidal neurons, which led to predictions that were confirmed in experiments using rat hippocampal slices, and may be an important feature of dendritic integration during mnemonic processing in the hippocampus. Expand
Dendritic spikes and activity-dependent synaptic plasticity
TLDR
The recent experimental and theoretical evidence for a role of regenerative dendritic activity in information processing within neurons and, especially, in activity-dependent synaptic plasticity is reviewed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites.
The temporal and spatial profile of activity-evoked changes in membrane potential and intracellular calcium concentration in the dendrites of hippocampal CA1 pyramidal neurons was examined withExpand
IPSPs modulate spike backpropagation and associated [Ca2+]i changes in the dendrites of hippocampal CA1 pyramidal neurons.
TLDR
The effects of synaptic inhibition on backpropagating Na+ spikes in the apical dendrites of CA1 pyramidal neurons in transverse slices from the rat hippocampus suggest that this effect of inhibition is different from its usual function in synaptic integration because spike generation and propagation down the axon are not significantly affected. Expand
Calcium-Dependent Persistent Facilitation of Spike Backpropagation in the CA1 Pyramidal Neurons
TLDR
It is found that depolarization and resultant Ca2+ influx into dendrites caused a persistent facilitation of spike backpropagation in the apical dendrite of CA1 pyramidal neuron by CaMKII-dependent mechanisms. Expand
Frequency-dependent propagation of sodium action potentials in dendrites of hippocampal CA1 pyramidal neurons.
TLDR
The results show that the action-potential amplitude and the spatial extent of their propagation in the dendrites is frequency dependent. Expand
Inhibitory control of somatodendritic interactions underlying action potentials in neocortical pyramidal neurons in vivo: An intracellular and computational study
TLDR
In the cat, in vivo intracellular recording and computational models of neocortical pyramidal cells suggest that inhibitory postsynaptic potentials can control the participation of proximal dendrites in somatic sodium spikes. Expand
Regenerative properties of pyramidal cell dendrites in area CA1 of the rat hippocampus.
TLDR
The results indicate that fast spikes in the distal parts of apical dendrites are generated by a local regenerative Na+ current and the transient outward K+Current, IA, and the Ca(2+)‐activated K+ current, IC, are involved in the repolarization of dendritic Na(+)‐dependent spikes. Expand
Calcium electrogenesis in distal apical dendrites of layer 5 pyramidal cells at a critical frequency of back-propagating action potentials.
TLDR
It is reported that layer 5 pyramidal neurons are very sensitive to a critical frequency of back-propagating action potentials varying between 60 and 200 Hz in different neurons, and the distal dendritic frequency sensitivity was suppressed by blockers of voltage-gated calcium channels, and also by synaptically mediated inhibition. Expand
Dendritic Spikes Are Enhanced by Cooperative Network Activity in the Intact Hippocampus
In vitro experiments suggest that dendritic fast action potentials may influence the efficacy of concurrently active synapses by enhancing Ca2+ influx into the dendrites. However, the exactExpand
Action potential initiation and propagation in rat neocortical pyramidal neurons
TLDR
It is concluded that both the apical dendrites and the axon of neocortical layer 5 pyramidal neurons in 4‐week‐old rats in P26–30 animals are capable of initiating regenerative potentials. Expand
Action potential propagation into the presynaptic dendrites of rat mitral cells
TLDR
It is concluded that voltage‐gated Na+ and K+ channels support dendritic APs with large amplitudes and short durations that may trigger fast transmitter release at dendrodendritic synapses in the olfactory bulb. Expand
...
1
2
3
4
5
...