Compartment model to describe peripheral arterial-venous drug concentration gradients with drug elimination from the venous sampling compartment.

Abstract

The central compartment of an n-compartment mammillary model was concatenated with a gradient compartment (i.e., venous sampling compartment) and with a conventional effect compartment to model arterial-venous drug concentration gradients and the arterial drug concentration vs effect relationship, respectively. To model drug metabolism during transit… (More)

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