Compartment-dependent management of H(2)O(2) by peroxisomes.

  title={Compartment-dependent management of H(2)O(2) by peroxisomes.},
  author={Reiner Fritz and Jutta Bol and Ulrike Hebling and Sabine Angerm{\"u}ller and Alfred V{\"o}lkl and H. Dariush Fahimi and Sebastian Mueller},
  journal={Free radical biology & medicine},
  volume={42 7},
Peroxisomes (PO) are essential and ubiquitous single-membrane-bound organelles whose ultrastructure is characterized by a matrix and often a crystalloid core. A unique feature is their capacity to generate and degrade H(2)O(2) via several oxidases and catalase, respectively. Handling of H(2)O(2) within PO is poorly understood and, in contrast to mitochondria, they are not regarded as a default H(2)O(2) source. Using an ultrasensitive luminometric H(2)O(2) assay, we show in real time that H(2)O… CONTINUE READING

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