Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

@inproceedings{Jhingran2015CompartmentSpecificAS,
  title={Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection},
  author={Anupam Jhingran and Shinji Kasahara and Kelly M Shepardson and Beth A. Fallert Junecko and Lena J. Heung and Debra K. Kumasaka and Sue E. Knoblaugh and Xin Lin and Barbara I Kazmierczak and Todd A. Reinhart and Robert A Cramer and Tobias M. Hohl},
  booktitle={PLoS pathogens},
  year={2015}
}
Aspergillus fumigatus forms ubiquitous airborne conidia that humans inhale on a daily basis. Although respiratory fungal infection activates the adaptor proteins CARD9 and MyD88 via C-type lectin, Toll-like, and interleukin-1 family receptor signals, defining the temporal and spatial pattern of MyD88- and CARD9-coupled signals in immune activation and fungal clearance has been difficult to achieve. Herein, we demonstrate that MyD88 and CARD9 act in two discrete phases and in two cellular… CONTINUE READING
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