Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors

@article{Nelson1999ComparisonsOH,
  title={Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors},
  author={D. Nelson and V. Lucaites and D. B. Wainscott and R. Glennon},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1999},
  volume={359},
  pages={1-6}
}
  • D. Nelson, V. Lucaites, +1 author R. Glennon
  • Published 1999
  • Biology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • Since the classical hallucinogens were initially reported to produce their behavioral effects via a 5-HT2 agonist mechanism (i.e., the 5-HT2 hypothesis of hallucinogen action), 5-HT2 receptors have been demonstrated to represent a family of receptors that consists of three distinct subpopulations: 5-HT2A, 5-HT2B, and 5-HT2C receptors. Today, there is greater support for 5-HT2A than for 5-HT2C receptor involvement in the behavioral effects evoked by these agents. However, with the recent… CONTINUE READING
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