• DOI:10.1248/bpb.b17-00978
Corpus ID: 49649466

Comparisons of Effects on Intestinal Short-Chain Fatty Acid Concentration after Exposure of Two Glycosidase Inhibitors in Mice.

@article{Xu2018ComparisonsOE,
  title={Comparisons of Effects on Intestinal Short-Chain Fatty Acid Concentration after Exposure of Two Glycosidase Inhibitors in Mice.},
  author={Guo-dong Xu and L. Cai and Yi-shu Ni and Shiyi Tian and Ying-Qi Lu and L. Wang and Lian-Lian Chen and W. Ma and S. Deng},
  journal={Biological & pharmaceutical bulletin},
  year={2018},
  volume={41 7},
  pages={
          1024-1033
        }
}

Guo-dong Xu, L. Cai, +6 authors S. Deng

Published 2018

Chemistry, Medicine

Biological & pharmaceutical bulletin

Acarbose and voglibose are the most widely used diabetes drugs as glycosidase inhibitors. In this study, the use of these two inhibitors significantly increased the content of starch in large intestine, and altered the concentration of short-chain fatty acids (SCFAs) by affecting the intestinal microbiota. However, there are some differences in the intestinal microbiome of the two groups of mice, mainly in bacteria such as Bacteroidaceae bacteroides and Desulfovibrionaceae desulfovibrio. The… CONTINUE READING

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