Comparison of uric acid and ascorbic acid in protection against EAE.

@article{Spitsin2002ComparisonOU,
  title={Comparison of uric acid and ascorbic acid in protection against EAE.},
  author={Sergei V. Spitsin and Gwen Scott and Tatiana Mikheeva and Anna Zborek and Rhonda B. Kean and Christine M. Brimer and Hilary Koprowski and D Craig Hooper},
  journal={Free radical biology & medicine},
  year={2002},
  volume={33 10},
  pages={1363-71}
}
Serum levels of uric acid (UA), an inhibitor of peroxynitrite- (ONOO-) related chemical reactions, became elevated approximately 30 million years ago in hominid evolution. During a similar time frame, higher mammals lost the ability to synthesize another important radical scavenger, ascorbic acid (AA), leading to the suggestion that UA may have replaced AA as an antioxidant. However, in vivo treatment with AA does not protect against the development of experimental allergic encephalomyelitis… CONTINUE READING

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