Comparison of univariate and multivariate linkage analysis of traits related to hypertension

@inproceedings{GrayMcGuire2009ComparisonOU,
  title={Comparison of univariate and multivariate linkage analysis of traits related to hypertension},
  author={Courtney L Gray-McGuire and Yeunjoo E. Song and Nathan J. Morris and Catherine M Stein},
  booktitle={BMC proceedings},
  year={2009}
}
Complex traits are often manifested by multiple correlated traits. One example of this is hypertension (HTN), which is measured on a continuous scale by systolic blood pressure (SBP). Predisposition to HTN is predicted by hyperlipidemia, characterized by elevated triglycerides (TG), low-density lipids (LDL), and high-density lipids (HDL). We hypothesized that the multivariate analysis of TG, LDL, and HDL would be more powerful for detecting HTN genes via linkage analysis compared with… CONTINUE READING
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