Comparison of two thiopental infusion rates for the induction of anaesthesia in dogs.

  title={Comparison of two thiopental infusion rates for the induction of anaesthesia in dogs.},
  author={Alexandra H A Dugdale and G L Pinchbeck and Ronald S Jones and Wendy A. Adams},
  journal={Veterinary anaesthesia and analgesia},
  volume={32 6},
OBJECTIVE To compare the induction dose requirements of thiopental using two different infusion rates for induction of anaesthesia in dogs. STUDY DESIGN Prospective, randomized study. ANIMALS Fifty, healthy (ASA I or II) client-owned dogs with a mean age of 4.1 years and a mean mass of 20.4 kg undergoing elective surgery. MATERIALS AND METHODS Animals were randomly assigned to receive an infusion of 2.5% thiopental at a rate of either 0.1 ml kg(-1) minute(-1) or 0.4 ml kg(-1)minute(-1… Expand
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The times for induction of anaesthesia were significantly greater with the slower infusion rates, and the effect of different rates of injection of thiopentone, methohexitone and etomidate was compared. Expand
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Induction dose and time are dependent on infusion rate in a complex manner, and residual dosecirculation was a factor in overdose and hemodynamic depression. Expand
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Effects of phenobarbital on thiopental pharmacokinetics in greyhounds.
  • R. Sams, W. Muir
  • Chemistry, Medicine
  • American journal of veterinary research
  • 1988
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The effective dose in 50% of the population for the laryngoscopic reflex was chosen as the end point for intubation, and the computed doses necessary to achieve this end point were 19.4mg of thiopental/kg, 18.4 mg of thiamylal/ kg, and 9.7 mg of methohexital/kg. Expand
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The cardiovascular and respiratory effects of 3 rapidly acting barbiturates, thiopental sodium, thiamylal sodium, and methohexital sodium, were studied in dogs from completion of injection until 12.5Expand
Influence of age and sex on the pharmacokinetics of thiopentone.
For all groups a significant correlation between initial drug concentration and k12 supported the hypothesis that there distribution rate constant k12 is the predominant factor in the pharmacokinetic profile of a dose of thiopentone sufficient to obtund the eyelash reflex. Expand