Comparison of two superparamagnetic viral-sized iron oxide particles ferumoxides and ferumoxtran-10 with a gadolinium chelate in imaging intracranial tumors.

@article{Vrallyay2002ComparisonOT,
  title={Comparison of two superparamagnetic viral-sized iron oxide particles ferumoxides and ferumoxtran-10 with a gadolinium chelate in imaging intracranial tumors.},
  author={P{\'e}ter V{\'a}rallyay and Gary M. Nesbit and Leslie L. Muldoon and Randal R Nixon and Johnny B. Delashaw and James Cohen and Annie Petrillo and Doris Rink and Edward A Neuwelt},
  journal={AJNR. American journal of neuroradiology},
  year={2002},
  volume={23 4},
  pages={510-9}
}
BACKGROUND AND PURPOSE Ultrasmall superparamagnetic iron oxide particles result in shortening of T1 and T2 relaxation time constants and can be used as MR contrast agents. We tested four hypotheses by evaluating MR images of intracranial tumors after infusion of two iron oxide agents in comparison with a gadolinium chelate: 1) Ferumoxtran in contrast to ferumoxides can be used as an intravenous MR contrast agent in intracranial tumors; 2) ferumoxtran enhancement, albeit delayed, is similar to… CONTINUE READING

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New MRI contrast agent for labeling of tumor-associated macrophages that stimulate tumor angiogenesis (abstr)

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