Comparison of two related lines of tauGFP transgenic mice designed for lineage tracing

@inproceedings{Sharp2017ComparisonOT,
  title={Comparison of two related lines of tauGFP transgenic mice designed for lineage tracing},
  author={Linda Sharp and Thomas Pratt and Gillian E. MacKay and Margaret A. Keighren and Jean H. Flockhart and Emma J. Chandler and David J. Price and John O. Mason and John D. West},
  booktitle={BMC Developmental Biology},
  year={2017}
}
The tauGFP reporter fusion protein is produced nearly ubiquitously by the TgTP6.3 transgene in TP6.3 mice and its localisation to microtubules offers some advantages over soluble GFP as a lineage marker. However, TgTP6.3 Tg/Tg homozygotes are not viable and TgTP6.3 Tg/− hemizygotes are smaller than wild-type. TP6.4 mice carry the TgTP6.4 transgene, which was produced with the same construct used to generate TgTP6.3, so we investigated whether TgTP6.4 had any advantages over TgTP6.3. Although… CONTINUE READING
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