Comparison of two methods to detect publication bias in meta-analysis.

  title={Comparison of two methods to detect publication bias in meta-analysis.},
  author={Jaime Peters and A. J. Sutton and David E Jones and Keith R. Abrams and Lesley Rushton},
  volume={295 6},
CONTEXT Egger's regression test is often used to help detect publication bias in meta-analyses. However, the performance of this test and the usual funnel plot have been challenged particularly when the summary estimate is the natural log of the odds ratio (lnOR). OBJECTIVE To compare the performance of Egger's regression test with a regression test based on sample size (a modification of Macaskill's test) with lnOR as the summary estimate. DESIGN Simulation of meta-analyses under a number… CONTINUE READING
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