Comparison of two indinavir/ritonavir regimens in the treatment of HIV-infected individuals.

@article{Acosta2004ComparisonOT,
  title={Comparison of two indinavir/ritonavir regimens in the treatment of HIV-infected individuals.},
  author={Edward P. Acosta and Hulin Wu and Scott M. Hammer and Song Yu and Daniel R. Kuritzkes and Ann Walawander and Joseph J Eron and Carl J. Fichtenbaum and Carla Pettinelli and Denise Neath and Elaine Okubo Ferguson and Alfred J. Saah and John G. Gerber},
  journal={Journal of acquired immune deficiency syndromes},
  year={2004},
  volume={37 3},
  pages={1358-66}
}
BACKGROUND Pharmacokinetic enhancement of protease inhibitors (PIs) with low-dose ritonavir (RTV) for salvage therapy is increasingly common. The purpose of this study was to compare the pharmacokinetics, safety, and tolerability of indinavir (IDV)/RTV at 800/200 mg (arm A) and 400/400 mg (arm B) administered twice daily in HIV-infected subjects failing their first PI-based regimen. METHODS A phase I/II, randomized, open-label, 24-week study was conducted. Formal 12-hour pharmacokinetic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…