Comparison of two aprotinin dosage regimens in pediatric patients having cardiac operations. Influence on platelet function and blood loss.

@article{Boldt1993ComparisonOT,
  title={Comparison of two aprotinin dosage regimens in pediatric patients having cardiac operations. Influence on platelet function and blood loss.},
  author={Joachim Boldt and Christoph Knothe and Bernfried Zickmann and N Wege and F F Dapper and Gunter Hempelmann},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={1993},
  volume={105 4},
  pages={705-11}
}
Only a few studies have reported on the effects of aprotinin in pediatric cardiac surgery, and the correct dose is controversial. In a prospective, randomized study, three groups of children weighing less than 20 kg were investigated. In group 1 (n = 14): aprotinin 20,000 U/kg was given after induction of anesthesia, 20,000 U/kg was added to the prime, and another 20,000 U/kg was given every hour of cardiopulmonary bypass (low-dose regimen). In group 2 (n = 14) aprotinin 35,000 U/kg was given… CONTINUE READING

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