Comparison of two antibodies for immunohistochemical evaluation of epidermal growth factor receptor expression in colorectal carcinomas, adenomas, and normal mucosa.

@article{Bhargava2006ComparisonOT,
  title={Comparison of two antibodies for immunohistochemical evaluation of epidermal growth factor receptor expression in colorectal carcinomas, adenomas, and normal mucosa.},
  author={Rohit Bhargava and Beiyun Chen and David S. Klimstra and Leonard Saltz and Cyrus Y. Hedvat and Laura H. Tang and William Gerald and Julie Teruya-Feldstein and Philip B. Paty and Jing Qin and Jinru Shia},
  journal={Cancer},
  year={2006},
  volume={106 8},
  pages={1857-62}
}
BACKGROUND Immunohistochemical staining for epidermal growth factor receptor (EGFR) has been used as a criterion for the selection of patients with colon cancer for anti-EGFR therapy. Two antibodies, the PharmDx kit and the 31G7 clone, are used commonly for immunohistochemistry by various laboratories. No comparative studies on the performance of these 2 antibodies are available. METHODS EGFR status was evaluated in 744 tissue microarray core samples from primary and metastatic colorectal… CONTINUE READING
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