Comparison of topical isosorbide mononitrate, topical diltiazem, and their combination in the treatment of chronic anal fissure.

@article{Bulu2013ComparisonOT,
  title={Comparison of topical isosorbide mononitrate, topical diltiazem, and their combination in the treatment of chronic anal fissure.},
  author={Hakan Buluş and Numan Varol and Adnan Taş and Ali Kağan Coşkun},
  journal={Asian journal of surgery},
  year={2013},
  volume={36 4},
  pages={165-9}
}
BACKGROUND/OBJECTIVE Chronic anal fissure is a painful condition that is associated with an increase in internal anal sphincter pressure. The main aim of this study is to evaluate the efficacy and adverse effects of topical isosorbide 5 mononitrate and topical diltiazem, when administered either as single agents or in combination, in the treatment of anal fissure. METHODS Patients with chronic anal fissure were enrolled in the study. They were randomized into three groups: Group A (0.2… CONTINUE READING
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