Comparison of topical interleukin-1 vs tumor necrosis factor-alpha blockade with corticosteroid therapy on murine corneal inflammation, neovascularization, and transplant survival (an American Ophthalmological Society thesis).

@article{Dana2007ComparisonOT,
  title={Comparison of topical interleukin-1 vs tumor necrosis factor-alpha blockade with corticosteroid therapy on murine corneal inflammation, neovascularization, and transplant survival (an American Ophthalmological Society thesis).},
  author={Reza Dana},
  journal={Transactions of the American Ophthalmological Society},
  year={2007},
  volume={105},
  pages={
          330-43
        }
}
  • Reza Dana
  • Published in
    Transactions of the American Ophthalmological…
    2007
PURPOSE Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) play critical roles in mediating corneal inflammation. In this study, topical blockade of IL-1 and TNF-alpha, alone or in combination, was compared to conventional corticosteroid anti-inflammatory therapy in suppressing infiltration of the cornea by antigen-presenting Langerhans cells (LCs) and in promoting corneal transplant survival in a mouse model of keratoplasty. METHODS Study drugs included topical 2% IL-1 receptor… CONTINUE READING

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