Comparison of titer and safety of live attenuated JEV vaccine prepared with virus strain at different passages

@inproceedings{Liping2005ComparisonOT,
  title={Comparison of titer and safety of live attenuated JEV vaccine prepared with virus strain at different passages},
  author={Zhao Li-ping},
  year={2005}
}
To study the influence of JEV virus strain at different passages on the quality of JEV vaccine. JEV vaccines were prepared with virus strain SA14-14-2 PHK7, PHK8 and PHK9, which were 7~ th,8~ th,9~ th passages respectively. The titers and safety of these JEV vaccines were tested. The average titer of JEV vaccines prepared with SA14-14-2 PHK7, PHK8 and PHK9 was 6.43 lg PFU/ml. The test for neurovirulence reversion in infant mice was 1.1 lg LD 50/0.03ml, which was negative. The biological… CONTINUE READING

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