Comparison of tigecycline penetration into the epithelial lining fluid of infected and uninfected murine lungs.

@article{Crandon2009ComparisonOT,
  title={Comparison of tigecycline penetration into the epithelial lining fluid of infected and uninfected murine lungs.},
  author={Jared L. Crandon and Aryun Kim and David P Nicolau},
  journal={The Journal of antimicrobial chemotherapy},
  year={2009},
  volume={64 4},
  pages={837-9}
}
OBJECTIVES When evaluating the pharmacodynamics of antimicrobials, assumptions are often made relative to their pharmacokinetics. One example of this is applying tissue penetration results of uninfected hosts to those displaying a targeted illness. As tigecycline evolves into a potential treatment option for pneumonia, we determined whether the presence of a lung infection affected the penetration of the drug into the epithelial lining fluid (ELF). METHODS Single doses of tigecycline 50 and… CONTINUE READING

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