Comparison of threshold selection methods for microarray gene co-expression matrices

@inproceedings{Borate2009ComparisonOT,
  title={Comparison of threshold selection methods for microarray gene co-expression matrices},
  author={Bhavesh Borate and Elissa J. Chesler and Michael A. Langston and Arnold M. Saxton and Brynn H. Voy},
  booktitle={BMC Research Notes},
  year={2009}
}
BackgroundNetwork and clustering analyses of microarray co-expression correlation data often require application of a threshold to discard small correlations, thus reducing computational demands and decreasing the number of uninformative correlations. This study investigated threshold selection in the context of combinatorial network analysis of transcriptome data.FindingsSix conceptually diverse methods - based on number of maximal cliques, correlation of control spots with expressed genes… CONTINUE READING

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