Comparison of three methods for estimating rates of synonymous and nonsynonymous nucleotide substitutions.

@article{Tzeng2004ComparisonOT,
  title={Comparison of three methods for estimating rates of synonymous and nonsynonymous nucleotide substitutions.},
  author={Yun-Huei Tzeng and Runsun Pan and Wen-Hsiung Li},
  journal={Molecular biology and evolution},
  year={2004},
  volume={21 12},
  pages={2290-8}
}
Three frequently used methods for estimating the synonymous and nonsynonymous substitution rates (Ks and Ka) were evaluated and compared for their accuracies; these methods are denoted by LWL85, LPB93, and GY94, respectively. For this purpose, we used a codon-evolution model to obtain the expected Ka and Ks values for the above three methods and compared the values with those obtained by the three methods. We also proposed some modifications of LWL85 and LPB93 to increase their accuracies. Our… CONTINUE READING
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