Comparison of three-factor and four-factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers.

@article{Levi2014ComparisonOT,
  title={Comparison of three-factor and four-factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers.},
  author={Marcel M. Levi and Kenneth T Moore and C F Castillejos and Dagmar Kubitza and Scott D. Berkowitz and Samuel Z. Goldhaber and M Raghoebar and Maulik R. Patel and Jeffrey I Weitz and Jerrold H Levy},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2014},
  volume={12 9},
  pages={1428-36}
}
BACKGROUND Four-factor prothrombin complex concentrates (PCCs), which contain factor II, FVII, FIX, and FX, have shown the potential to reverse the anticoagulant effect of rivaroxaban in healthy volunteers. The purpose of this study was to determine whether a three-factor PCC, which contains little FVII, has a similar effect. METHODS AND RESULTS We performed an open-label, single-center, parallel-group study comparing the effect of a three-factor PCC (Profilnine SD) with that of a four-factor… CONTINUE READING
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Efficacy and safety of a four-factor pro© 2014 International Society on Thrombosis and Haemostasis

  • R Sarode, TJ JrMilling, +4 authors JN. Goldstein
  • 2014

Xarelto (rivaroxaban) Summary of Product Characteristics

  • AG BayerPharma
  • Available at: http://www.ema.europa.eu/ docs…
  • 2013

Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model

  • A Godier, A Miclot, +6 authors CM. Samama
  • Anesthesiology
  • 2012

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