Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

@article{Nakagawa2018ComparisonOT,
  title={Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice},
  author={Yuta Nakagawa and Kana Ishimura and Satomi Oya and Masaki Kamino and Y. Fujii and Fumio Nanba and T. Toda and Takeshi Ishii and Takahiro Adachi and Y. Suhara and N. Osakabe},
  journal={PLoS ONE},
  year={2018},
  volume={13}
}
  • Yuta Nakagawa, Kana Ishimura, +8 authors N. Osakabe
  • Published 2018
  • Chemistry, Medicine
  • PLoS ONE
  • Objectives We previously found that elevated energy expenditure following a single oral dose of flavan 3-ols (FL), a mixture of catechins and B type procyanidins, is caused by sympathetic nerve activation. In the present study, we compared the activity of the FL components (-)-epicatechin (EC; monomer), procyanidin B2 (B2; dimer), procyanidin C1 (C1; trimer), cinnamtannin A2 (A2; tetramer), and more than pentamer fraction (P5). Methods Male ICR mice were treated with a single oral dose of FL… CONTINUE READING
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